Celebrating the beautiful bond of friendship and sisterhood on National Sisters Day, these Bible verses perfectly capture the love, loyalty, and support that define true sisters and best friends. Whether bound by blood or spirit, sisters uplift each other through life’s challenges and joys.
These verses offer encouragement, wisdom, and inspiration, reminding us of God’s design for friendship and the strength found in sisterly love. Let these scriptures deepen your appreciation for your best friend or sister, and serve as a heartfelt tribute to the sacred connections that enrich our lives.
1. Trustworthy Counsel: Proverbs 27:9
"Perfume and incense bring joy to the heart, and the pleasantness of a friend springs from their heartfelt advice."

This verse emphasizes the value of genuine friends who offer wise, loving counsel. Like a comforting fragrance, a sister’s honest advice refreshes our spirits and brings joy. It reminds us that the best friendships are rooted in trust and the willingness to uplift one another with kindness and truth.
2. Unwavering Love: Proverbs 17:17
"A friend loves at all times, and a brother is born for a time of adversity."
This verse highlights the steadfast nature of true friendship and sisterhood. A real friend is consistent through every season, whether in joy or hardship. Just like a brother (or sister) is there during tough times, this scripture reminds us that sisters are divinely meant to support one another, embodying unwavering love and loyalty no matter the circumstances. It’s a beautiful affirmation of the enduring bond that sisters share.
3. Joy in Companionship: Ecclesiastes 4:9-10
"Two are better than one, because they have a good return for their labor: If either of them falls down, one can help the other up."
Here, the Bible celebrates companionship and mutual support, which are at the heart of sisterhood and best friendship. When life challenges us, having someone to lean on makes all the difference. This verse encourages us to cherish our sisters and friends who lift us up when we stumble, doubling the joy and halving the struggles we face.
4. Strength in Unity: Psalm 133:1
"How good and pleasant it is when God’s people live together in unity!"
Unity among sisters or best friends is a powerful testimony of God’s love. This verse celebrates the joy and goodness found when hearts align in harmony. Sisters who stand united provide a source of strength and encouragement, reflecting the beauty of God’s design for community and fellowship.
5. Loyalty and Faithfulness: Proverbs 3:3
"Let love and faithfulness never leave you; bind them around your neck, write them on the tablet of your heart."
This scripture teaches us the importance of loyalty and faithfulness in relationships. Sisters and best friends embody these virtues by standing firmly by each other’s side through every season. It encourages us to cherish and nurture these qualities, ensuring that our bonds remain strong and heartfelt.
6. Encouraging One Another: 1 Thessalonians 5:11
"Therefore encourage one another and build each other up, just as in fact you are doing."
Encouragement is a vital part of any meaningful friendship or sisterly bond. This verse reminds us to actively support and uplift our loved ones with positive words and actions. On National Sisters Day, it’s a perfect reminder to celebrate how sisters build each other up, fueling hope and confidence in each other’s lives.
7. Compassion and Forgiveness: Colossians 3:13
"Bear with each other and forgive one another if any of you has a grievance against someone. Forgive as the Lord forgave you."

Sisterhood and friendship aren’t always perfect, but this verse highlights the importance of patience, compassion, and forgiveness. Just as God forgives us, sisters are called to extend grace to one another, allowing love to heal and restore even the toughest conflicts.
8. Faithful Companionship: Ruth 1:16
"Where you go I will go, and where you stay I will stay. Your people will be my people and your God my God."
Ruth’s promise to Naomi exemplifies unwavering loyalty and commitment between friends or sisters. This powerful declaration shows how true friendship means walking together through every chapter of life, sharing not only moments but also faith and purpose.
9. Joyful Fellowship: Proverbs 27:17
"As iron sharpens iron, so one person sharpens another."
Friendship and sisterhood refine and strengthen us, much like iron sharpens iron. This verse reminds us that close relationships challenge us to grow, improve, and become our best selves. The influence of a true sister or best friend is both inspiring and transformative.
10. Comfort in Friendship: 2 Corinthians 1:4
"He comforts us in all our troubles, so that we can comfort those in any trouble with the comfort we ourselves receive from God."
This verse highlights the reciprocal nature of comfort in sisterhood. God’s comfort equips us to support and console our sisters and friends during difficult times. It’s a beautiful reminder that through shared empathy, sisters carry each other’s burdens and reflect God’s love.
11. Faithful Love: Song of Solomon 8:6
"Place me like a seal over your heart, like a seal on your arm; for love is as strong as death, its jealousy unyielding as the grave."
This poetic verse expresses the enduring and powerful nature of love, which is fitting for the deep bond between sisters and best friends. Love is portrayed as unwavering and eternal, emphasizing the sacredness of these relationships.
12. Trust in Friendship: Proverbs 18:24
"One who has unreliable friends soon comes to ruin, but there is a friend who sticks closer than a brother."
This verse reminds us to cherish friends who are steadfast and reliable, just like sisters who stand by us through thick and thin. True friends and sisters are invaluable, offering loyalty that surpasses ordinary bonds and protects us from ruin.
13. Mutual Support: Galatians 6:2
"Carry each other’s burdens, and in this way you will fulfill the law of Christ."
Sisters and best friends embody this scripture by sharing each other’s struggles and joys. Supporting one another is a divine calling that strengthens relationships and reflects Christ’s love in action.
14. Rejoicing Together: Romans 12:15
"Rejoice with those who rejoice; mourn with those who mourn."
This verse calls us to empathetic fellowship, sharing both happiness and sorrow with our sisters and best friends. It highlights the emotional depth of these relationships and the importance of being present for one another.
15. Rooted in Love: 1 Corinthians 13:4-7
"Love is patient, love is kind. It does not envy, it does not boast, it is not proud…"
Often called the love chapter, this passage describes the qualities that make sisterhood and friendship thrive. Patience, kindness, humility, and perseverance define love that lasts, inspiring us to cultivate these virtues in our closest relationships.
16. Peaceful Relationships: Romans 12:18
"If it is possible, as far as it depends on you, live at peace with everyone."
This verse encourages harmony and peace in relationships, including those with sisters and best friends. It reminds us to strive for peaceful connections, even amidst disagreements, to nurture a loving and supportive environment.
17. God’s Gift of Friendship: John 15:13
"Greater love has no one than this: to lay down one’s life for one’s friends."
Jesus’ words illustrate the ultimate sacrifice that defines true friendship and sisterhood. It’s a reminder of the depth of love and commitment that binds sisters and best friends, willing to put others’ needs before their own.
18. Patience and Kindness: Ephesians 4:2
"Be completely humble and gentle; be patient, bearing with one another in love."

Humility, gentleness, and patience are key to nurturing lasting friendships. This verse calls sisters to embrace these traits, creating a loving atmosphere where both can grow and flourish together.
19. Encouraging Words: Proverbs 16:24
"Gracious words are a honeycomb, sweet to the soul and healing to the bones."
The power of kind, uplifting words cannot be overstated in close relationships. This verse encourages us to speak life and sweetness into the hearts of our sisters and best friends, fostering healing and joy.
20. Building Each Other Up: Hebrews 10:24-25
"And let us consider how we may spur one another on toward love and good deeds, not giving up meeting together…"
This scripture speaks to the importance of continual fellowship and mutual encouragement. Sisters and best friends inspire each other to grow spiritually and emotionally, strengthening their bonds through shared faith and love.
21. A Friendship Blessed by God: James 1:17
"Every good and perfect gift is from above, coming down from the Father of the heavenly lights…"
True friendship is a precious gift from God. This verse reminds us to be grateful for the blessing of sisters and best friends, recognizing their presence as a divine provision in our lives.
Anne Kostick has been Editor-in-Chief since September 2007. Previously, Anne was a principal at Foxpath IND, a publishing, consulting and editorial services company specializing in the transition to and from traditional content publishing and online content management, development and publishing. Her clients included trade book publishers, technology and financial services Web sites, and arts and cultural institutions. Previously, she worked as Licensing and Product Development Director, Senior Acquisitions Editor and Director of Electronic Publishing for Workman Publishing, and as Senior Acquisitions Editor for Harry N. Abrams/Stewart, Tabori & Chang. In the online world she worked as Director of Content Development for Vitaminshoppe.com. Anne has a B.A. in Greek and Latin, with a minor in Theater, from Beloit College. She is the author of several books for children, as well as a definitive collection of jokes.