A multi-celled human embryo
Genetically Modified Embryos Raise Concerns
by
findingDulcinea Staff
Scientists announce they have genetically altered a human embryo for the first time, prompting worry that “designer babies” with preselected traits could be next.
30-Second Summary
The genetic research focused on stem cells and used an abnormal embryo unable to develop into a baby, says Dr. Zev Rosenwaks, director of the Center for Reproductive Medicine and Infertility at New York Presbyterian/Weill Cornell Medical Center.
Using techniques developed in animal research, the scientists inserted a gene that acts as a marker into the embryo cells, tracing whether the embryo’s stem cells later contained the marker gene. Such work could help shed light on why abnormal embryos fail to develop, Rosenwaks told Newsweek.
But the methods used in the Weill Cornell study could lead to genetically modified people, cautions Marcy Darnovsky of the Center for Genetics and Society. Critics worry that future scientists will produce babies with hand-picked traits such as intelligence or athletic ability, creating a society where some are considered genetically inferior.
Rosenwaks doubts the validity of such fears. “None of us wants to make designer babies,” he said.
Still, Richard Hayes, the executive director of the Center, says that new human genetic technologies may have potential to cure diseases, but they could also do serious harm. “If misapplied, they would exacerbate existing inequalities and reinforce existing modes of discrimination,” Hayes wrote in The Washington Post. “If more widely abused, they could undermine the foundations of civil and human rights.”
As genetic research techniques move forward, the government is starting to take precautions. In April, the Senate passed the Genetic Information Nondiscrimination Act, which would bar employers and health insurers from using information about a person’s genes to penalize them.
Using techniques developed in animal research, the scientists inserted a gene that acts as a marker into the embryo cells, tracing whether the embryo’s stem cells later contained the marker gene. Such work could help shed light on why abnormal embryos fail to develop, Rosenwaks told Newsweek.
But the methods used in the Weill Cornell study could lead to genetically modified people, cautions Marcy Darnovsky of the Center for Genetics and Society. Critics worry that future scientists will produce babies with hand-picked traits such as intelligence or athletic ability, creating a society where some are considered genetically inferior.
Rosenwaks doubts the validity of such fears. “None of us wants to make designer babies,” he said.
Still, Richard Hayes, the executive director of the Center, says that new human genetic technologies may have potential to cure diseases, but they could also do serious harm. “If misapplied, they would exacerbate existing inequalities and reinforce existing modes of discrimination,” Hayes wrote in The Washington Post. “If more widely abused, they could undermine the foundations of civil and human rights.”
As genetic research techniques move forward, the government is starting to take precautions. In April, the Senate passed the Genetic Information Nondiscrimination Act, which would bar employers and health insurers from using information about a person’s genes to penalize them.
Headline Link: ‘Genetically modified human embryo stirs criticism’
The study, the first report of genetic modification of a human embryo, was presented last fall to the American Society for Reproductive Medicine. Researchers used an embryo that had extra chromosomes, making it nonviable. Following a standard procedure used in animals, they inserted a gene that acts as a marker that can be easily followed over time. The embryo cells took up the gene, Rosenwaks said. Many observers criticized the research and its potential to encourage genetic modification of humans, but Kathy Hudson, director of the Genetics and Public Policy Center in Washington, D.C., said she was not troubled and “the idea of successfully modifying babies by inserting genes remains a technically daunting challenge.”
Source: Newsweek
Related Topics: The Genetic Information Nondiscrimination Act, stem cells turned into heart cells
After stalling in Congress for years, a bill banning genetic discrimination was passed on May 1. It makes it illegal for employers and health insurers to penalize people for genetic flaws or disease risks.
Source: The Boston Globe (subscription may be required)
A team of researchers succeeded in turning embryonic stem cells into key heart cells. Such cells could eventually be used to help treat heart conditions in humans.
Source: findingDulcinea
Opinion & Analysis: ‘Genetically Modified Human? No Thanks’
Richard Hayes gives his response to an essay by Dartmouth ethics professor Ronald Green. “Granted, new human genetic technologies have real potential to help prevent or cure many terrible diseases, and I support research directed towards that end. But these same technologies also have the potential for real harm.”
Source: The Washington Post (free registration may be required)
Reference: Genetics & Public Policy Center, the National Human Genome Research Institute
The Web site of the Genetics & Public Policy Center, which aims to help policy leaders, decision makers, and the public better understand human genetics, includes a section with news updates about the rapidly evolving field.
Source: Genetics & Public Policy Center
The National Human Genome Research Institute gives an overview of genetic discrimination.
Source: The National Human Genome Research Institute







